Product Details: Ortho Adapt

Ortho Adapt

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DISCUSSION: Ortho•Adapt is our premier adaptogenic formula. Includes porcine adrenal tissue and cortex to provide needed peptides and cofactors, along with Pantethine (the “activated” form of pantothenic acid [vitamin B5]), and botanical adaptogens. Supports the body’s ability to respond to stress with balanced, proactive energy rather than alarm or exhaustion. Also available in a vegetarian formula.


Product Code Size Servings
 AOR08013 120 Vegi-Caps 30 Servings

Supplement Facts

Serving Size: 4 Capsules
Servings per Container: 30
 Amount Per Serving %Daily Value
Vitamin C 500mg 833%
Vitamin B5 (as Pantethine) 200mg 2000%
Adrenal Tissue (Medulla and Cortex) (Porcine) 450mg  †
Licorice (root) extract (Glycyrrhiza glabra) (20% glyzyrrhizin) 800mg  †
Eleutherococcus senticosus extract (0.8% eleutherosides) 200mg
Rhodiola rosea (root) extract (1% salidroside) 150mg
Ashwagandha (Withania somnifera) extract (2.5% withanolides) 200mg
*% Daily Values Based on 2000 Calorie Diet
† Daily value not established
Other ingredients: microcrystalline cellulose, silicon dioxide. Capsule: gelatin, water.

Note: Herbal extracts will naturally vary in color from one batch to another.

AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish or shellfish.

Suggested Use
Begin with one capsule daily with a meal, and increase to personal optimal level (up to four capsules daily) or as directed by a qualified health consultant.


Pregnancy / Nursing
No studies; do not take.

Persons with high blood pressure, impaired liver or kidney function, heart disease, hypertonia, or severe kidney disease, Cushing's Syndrome, or who are pregnant or breastfeeding should not take this product. Consult a health care practitioner before taking if you have diabetes or hypokalemia, or if you are taking any kind of hormonal therapies, diuretics, potassium depleting agents, or MAO inhibitors.

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Magnesium/Potassium Aspartates
120 Vegi-Caps

Magnesium/Potassium Aspartates

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.

Copyright © 2011, Advanced Orthomolecular Research


A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work.
Phytomedicine. 2003 Mar; 10(2-3): 95-105.
Shevtsov VA, Zholus BI, Shervarly VI, Vol'skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G.

A randomized, double-blind, placebo-controlled, parallel-group clinical study with an extra non-treatment group was performed to measure the effect of a single dose of standardized SHR-5 Rhodiola rosea extract on capacity for mental work against a background of fatigue and stress. An additional objective was to investigate a possible difference between two doses, one dose being chosen as the standard mean dose in accordance with well-established medicinal use as a psychostimulant/adaptogen, the other dose being 50% higher. Some physiological parameters, e.g. pulse rate, systolic and diastolic blood pressure, were also measured. The study was carried out on a highly uniform population comprising 161 cadets aged from 19 to 21 years. All groups were found to have very similar initial data, with no significant difference with regard to any parameter. The study showed a pronounced antifatigue effect reflected in an antifatigue index defined as a ratio called AFI. The verum groups had AFI mean values of 1.0385 and 1.0195, 2 and 3 capsules respectively, whilst the figure for the placebo group was 0.9046. This was statistically highly significant (p < 0.001) for both doses (verum groups), whilst no significant difference between the two dosage groups was observed. There was a possible trend in favour of the lower dose in the psychometric tests. No such trend was found in the physiological tests.

Therapeutic action of pantothenic acid.
Int J Vitam Nutr Res Suppl. 1983; 24: 53-67.
Fidanza A.

Summary: Pantothenic acid plays a fundamental role in cellular physiology as a constituent of coenzyme A and as such it intervenes in the metabolism of lipids; in addition to that, in the form of active acetate, it is the precursor of cholesterol and of steroid hormones. An adequate vitamin intake is essential for tissue trophism, especially for the epithelial tissue, and for the functioning of organs and systems. The manifestations peculiar to the deficiency particularly involve the adrenal glands and the gonads, with particularly serious hypofunction pictures: lesions of the skin and of the mucosac are also observed with alterations of the cutaneous adnexes and in particular the hair. Moreover, through its intervention in the synthesis reaction of acetylcholine, the vitamin is capable of stimulating the depressed intestinal peristalis and is therefore extensively used for the resolution of postoperative paralytic ileus.

Researches carried out in our laboratories in recent years have revealed that in rats, after administration of high amounts of pantothenic acid, there occurs an increase in hepatic and seric cholesterol; urinary 17-ketosteroid elimination is increased as well as the total amount of corticosteroids in adrenal cortex. In the course of recent experiments performed on humans, we could observe that, following administration of high doses of oral panthenol, a considerable increase is recorded in the urinary elimination of 17,21 dihydroxy-20 ketosteroids, an unmistakable sign of a functional activation of the adrenal gland. On the basis of our researches, we deem it advisable to suggest the therapeutic use of this vitamin in the corticosuprarenal hypofunction forms, in the reactivation of the intestinal mobility, and in all those conditions in which the structure of the skin, of the cutaneous adnexes and of the mucosae is altered.

[Adrenal cortex functional activity in pantothenate deficiency and the administration of the vitamin or its derivatives]
Vopr Pitan. 1985 Jul-Aug; (4): 51-4.
Tarasov IuA, Sheibak VM, Moiseenok AG.

Study of the corticosteroid content in the adrenals and blood of rats under pantothenate deficiency has demonstrated a decrease in adrenocortical function. A single administration of pantothenate in a dose of 3.3 mg/kg reduced the influence of hypovitaminosis on the adrenals. The pantothenate derivatives (pantethine, 4'-phosphopantothenate and CoA in particular) injected to intact animals in a single dose equimolar to 3.3 mg/kg calcium pantothenate per kg bw had a marked steroidogenous effect.

Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: an experimental study.
Phytomedicine. 2000 Dec; 7(6): 463-9.
Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S.

The roots of Withania somnifera (WS) are used extensively in Ayurveda, the classical Indian system of medicine, and WS is categorized as a rasayana, which are used to promote physical and mental health, to provide defence against disease and adverse environmental factors and to arrest the aging process. WS has been used to stabilize mood in patients with behavioural disturbances. The present study investigated the anxiolytic and antidepressant actions of the bioactive glycowithanolides (WSG), isolated from WS roots, in rats. WSG (20 and 50 mg/kg) was administered orally once daily for 5 days and the results were compared by those elicited by the benzodiazepine lorazepam (0.5 mg/kg, i.p.) for anxiolytic studies, and by the tricyclic anti-depressant, imipramine (10 mg/kg, i.p.), for the antidepressant investigations. Both these standard drugs were administered once, 30 min prior to the tests. WSG induced an anxiolytic effect, comparable to that produced by lorazepam, in the elevated plus-maze, social interaction and feeding latency in an unfamiliar environment, tests. Further, both WSG and lorazepam, reduced rat brain levels of tribulin, an endocoid marker of clinical anxiety, when the levels were increased following administration of the anxiogenic agent, pentylenetetrazole. WSG also exhibited an antidepressant effect, comparable with that induced by imipramine, in the forced swim-induced 'behavioural despair' and 'learned helplessness' tests. The investigations support the use of WS as a mood stabilizer in clinical conditions of anxiety and depression in Ayurveda.

The influence of active components of Eleutherococcus senticosus on cellular defence and physical fitness in man.
Phytother Res. 2000 Feb; 14(1): 30-5.
Szolomicki J, Samochowiec L, Wojcicki J, Drozdzik M, Szolomicki S.

The influence of active components of Eleutherococcus senticosus, contained in Taiga Wurzel preparation, were studied on cellular defence and physical fitness in man. 50 healthy volunteers of both sexes were selected, and basic clinical examination and laboratory tests were performed in all subjects. All were randomly subdivided into two study groups: group A with 35 subjects receiving Taiga Wurzel and group B with 15 subjects receiving Echinacea. 20 healthy males were randomly selected from both groups and underwent an ergospirometric study. The preparations were administered for 30 days as follows: Taiga Wurzel 25 drops three times daily, Echinacea 40 drops three times daily. After 1 month blood was drawn for control tests. Changes in the following blood parameters were observed in comparison to initial values in group A: total and LDL cholesterol, triglycerides and glucose. No alterations were seen in group B. The ergospirometric test revealed a higher oxygen plateau in group A (Taiga Wurzel). On the basis of the present study the following conclusions were drawn: active components in Eleutherococcus senticosus contained in Taiga Wurzel preparation affect cellular defence and physical fitness, as well as lipid metabolism. Copyright 2000 John Wiley & Sons, Ltd.

Vitamin C attenuates the physiological response to stress.
Book of Abstracts, 218th ACS National Meeting. 1999; 79.
O'Keefe MP, Scholz C, Campbell PS.

The purpose of this study was to determine if vitamin C could act through the endocrine system to bolster immune function by limiting the secretion of anti-inflammatory adrenal corticoids. Rats were fed 50mg or 100mg of vitamin C twice daily at twelve-hour intervals for a period of three weeks. Stress was produced daily by one hour of complete physical restraint. Rats were euthanized by CO2 narcosis and blood obtained by cardiac puncture. RIA and ELISA were used to measure corticosterone and IgG, respectively. Vitamin C treatment at 200mg/day increased the serum IgG levels and alleviated the physiological response to stress, preventing the morning elevation of blood corticosterone produced by immobilization. Adrenal hypertrophy and thymus involution were also more pronounced under stress without vitamin C. We conclude that vitamin C may reduce the debilitation and illness associated with chronic stress by inhibiting glucocorticoid secretion and thus immunosuppression.

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. Any reproduction in whole or part and in print or electronic form without express permission is strictly forbidden. Permission to reproduce selected material may be granted by contacting AOR Inc.

Copyright © 2011, Advanced Orthomolecular Research

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